Mercedes-Benz E-Class trim comparison
2025 Mercedes-Benz E-Class E 350 vs E 450 4MATIC
The E-Class E 350 starts at $62,450 while the E 450 4MATIC is $70,850. That $8,400 gap buys 7 meaningful differences.
This is a powertrain and drivetrain change. The E 450 4MATIC gets the 3.0L I6 mild-hybrid Turbo and AWD, so the $8,400 is buying a different driving experience, not just nicer trim.
Choose the E 350 if the 2.0L I4 mild-hybrid Turbo with RWD already covers the way you drive. Move to the E 450 4MATIC only when the 3.0L I6 mild-hybrid Turbo and AWD combo is the reason you are shopping higher, because that is the real hardware split here.
If you are budgeting this move monthly, the jump from the E 350 to the E 450 4MATIC is about $148/month on a 60-month loan at 6.5% APR with 10% down. That works out to roughly $8,880 more by the time interest is counted. The payment only makes sense if that different powertrain matters to the way you actually drive, tow, or live with the vehicle.
Lock one trim, change the other side, and move through exact pair pages without resetting back to the full lineup every time.
Who notices the difference
The higher trim starts to make more sense when you are specifically shopping for the stronger powertrain, not just more trim content.
When both feel the same
Both the E 350 and E 450 4MATIC share the same 9-speed shiftable automatic transmission and identical wheelbase and body dimensions.
The upgrade math
You are paying $8,400 for 6 measurable differences, which works out to about $1,400 per change.
Key Differences at a Glance
This is the fast read: price, power, efficiency, and the feature flips most likely to change the answer.
Every Difference, Side by Side
This is the full read behind the quick decision signals above: the complete hardware, comfort, and equipment story. 7 specification differences, 0 shared.
Full Specification Comparison
Specifications reflect available data as of early 2025. Confirm details with an authorized dealer before purchasing.
| Spec | E 350 | E 450 4MATIC |
|---|---|---|
| Pricing | ||
| MSRP | $62,450 | $70,850 |
| Powertrain | ||
| Engine | 2.0L I4 mild-hybrid Turbo | 3.0L I6 mild-hybrid Turbo |
| Horsepower | 255 hp | 375 hp |
| Torque | 295 lb-ft | 369 lb-ft |
| Transmission | 9-speed shiftable automatic | 9-speed shiftable automatic |
| Drivetrain | RWD | AWD |
| Fuel Economy | ||
| City MPG | 25 | 22 |
| Highway MPG | 33 | 31 |
| Combined MPG | 28 | 25 |
| Fuel Tank | 17.4 gal | 17.4 gal |
| Annual Fuel Cost (EPA) | $2,050/yr | No published data |
| Dimensions | ||
| Curb Weight | 4,134 lbs | 4,376 lbs |
| Wheelbase | 116.6" | 116.6" |
| Length | 194.9" | 194.9" |
| Width | 74.0" | 74.0" |
| Height | 57.9" | 57.9" |
| Warranty | ||
| Bumper-to-Bumper | 4yr/50k | 4yr/50k |
| Powertrain | 4yr/50k | 4yr/50k |
| Corrosion | 4yr/50k | 4yr/50k |
| Roadside Assistance | 4yr/50k | 4yr/50k |
Data sources: licensed third-party automotive data, EPA fueleconomy.gov, NHTSA, and official manufacturer materials. Values marked est. are estimated.
2025 Mercedes-Benz E-Class E 350 vs E 450 4MATIC Questions Shoppers Ask
Use this page for the direct trim answer, then zoom back out to the Mercedes-Benz E-Class lineup, the Mercedes-Benz brand hub, the Midsize Sedans, the how to pick a trim guide, or our mid-trim value research when you need the bigger shopping path behind this one matchup.
How much more does the 2025 E-Class E 450 4MATIC cost than the E 350?
The E 450 4MATIC starts at $70,850 compared to $62,450 for the E 350. That is a $8,400 difference, or approximately $148/month more on a 60-month loan.
Do the 2025 Mercedes-Benz E-Class E 350 and E 450 4MATIC have the same engine?
No. The E 350 uses a 2.0L I4 mild-hybrid Turbo (255 hp, 295 lb-ft), while the E 450 4MATIC has the 3.0L I6 mild-hybrid Turbo (375 hp, 369 lb-ft). That is 120 more horsepower. Both pair with the same 9-speed shiftable automatic.
Does the 2025 E-Class E 350 come with AWD?
No. The E 350 comes standard with RWD while the E 450 4MATIC has AWD. This affects traction, fuel economy, and curb weight.
What warranty does the 2025 Mercedes-Benz E-Class come with?
All 2025 Mercedes-Benz E-Class trims, including both the E 350 and E 450 4MATIC, come with Mercedes-Benz's standard warranty: 4yr/50k bumper-to-bumper and 4yr/50k powertrain coverage. Warranty does not vary by trim level.
Is the 2025 Mercedes-Benz E-Class E 450 4MATIC worth $8,400 more than the E 350?
The E 450 4MATIC changes both the engine and drivetrain for $8,400 more. That is a hardware upgrade, not just a feature bump.
Which 2025 Mercedes-Benz E-Class trim gets better fuel economy, the E 350 or the E 450 4MATIC?
The E 350 is the more efficient of the two at 28 combined MPG, versus 25 for the other trim. That matters most if you are balancing running costs against the extra power, drivetrain, or comfort equipment tied to the pricier trim.
The Full Story Behind This Price Gap
Use the direct answer above for this exact matchup, then use these guides to understand whether you are really looking at a feature step-up, a package shuffle, or the point where the lineup starts changing in a meaningful way.
What $8,400 Gets You
The E-Class E 450 4MATIC is a clear upgrade over the E 350. The $8,400 price increase gets you the 3.0L I6 mild-hybrid Turbo engine (+120 hp) and AWD -- real functional changes, not just cosmetics.
E 350 vs. E 450 4MATIC: Day-to-Day
The E 450 4MATIC comes with the 3.0L I6 mild-hybrid Turbo instead of the E 350's 2.0L I4 mild-hybrid Turbo. That means 120 more horsepower and 74 more lb-ft of torque. That extra power shows up most clearly once you are out of town and asking more of the drivetrain. The cost of that extra capability is roughly 3 fewer combined MPG. The E 450 4MATIC has AWD while the E 350 has RWD. This affects traction, weight, and fuel economy.
Fuel Economy Comparison
The E-Class E 350 gets 3 more combined MPG. At $3.50/gallon and 12,000 miles/year, that saves roughly $180 per year or $900 over five years of ownership.
Summary
$8,400 more for the E-Class E 450 4MATIC gets you 6 real differences. At $148/month more, the question is whether those specific changes are things you will use regularly.
Trim-Matched Accessories
These add-ons are split by trim intent so the recommendations follow the actual use case, not just the same repeated product block.
Mercedes-Benz E-Class E 350
Value-trim add-onsThese picks fit the E 350 best when the goal is covering the daily-use gaps without paying up to the next trim.
Mercedes-Benz E-Class E 450 4MATIC
Step-up trim add-onsThese picks suit the E 450 4MATIC when you want the accessories to match the nicer cabin, broader utility, or more premium use case.
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Specifications shown combine licensed third-party automotive data with official manufacturer, EPA, and NHTSA source material for the 2025 model year. Actual pricing, features, and availability may vary by region and dealer. Always confirm details with an authorized dealer before making a purchase decision. TrimAtlas is not affiliated with Mercedes-Benz or any dealership.
Page updated 2026-03-18. Verify equipment, pricing, and regional availability with the manufacturer or dealer.