Mercedes-Benz E-Class trim comparison
2025 Mercedes-Benz E-Class E 350 4MATIC vs E 450 4MATIC
The E-Class E 350 4MATIC starts at $64,950 while the E 450 4MATIC is $70,850. That $5,900 gap buys 6 meaningful differences.
This trim jump changes the engine from 2.0L I4 mild-hybrid Turbo to 3.0L I6 mild-hybrid Turbo. Everything else is secondary to whether that powertrain difference matters for how you drive.
If you would notice the 3.0L I6 mild-hybrid Turbo every week, the E 450 4MATIC makes sense. If not, the E 350 4MATIC is the cleaner stop because this jump matters for the powertrain first and the trim badge second.
Think about this as a monthly tradeoff, not just a sticker gap. The E 450 4MATIC adds about $104/month on a typical 60-month loan, or around $6,240 more overall with interest. If that different powertrain is not part of your real use case, the cheaper trim keeps more money in your pocket without changing the core experience you need.
Lock one trim, change the other side, and move through exact pair pages without resetting back to the full lineup every time.
Who notices the difference
The higher trim starts to make more sense when you are specifically shopping for the stronger powertrain, not just more trim content.
When both feel the same
The E 350 4MATIC and E 450 4MATIC are mechanically identical where it counts: the same 9-speed shiftable automatic transmission and identical wheelbase and body dimensions.
The upgrade math
You are paying $5,900 for 5 measurable differences, which works out to about $1,180 per change.
Key Differences at a Glance
This is the fast read: price, power, efficiency, and the feature flips most likely to change the answer.
Every Difference, Side by Side
This is the full read behind the quick decision signals above: the complete hardware, comfort, and equipment story. 6 specification differences, 1 shared.
Full Specification Comparison
Specifications reflect available data as of early 2025. Confirm details with an authorized dealer before purchasing.
| Spec | E 350 4MATIC | E 450 4MATIC |
|---|---|---|
| Pricing | ||
| MSRP | $64,950 | $70,850 |
| Powertrain | ||
| Engine | 2.0L I4 mild-hybrid Turbo | 3.0L I6 mild-hybrid Turbo |
| Horsepower | 255 hp | 375 hp |
| Torque | 295 lb-ft | 369 lb-ft |
| Transmission | 9-speed shiftable automatic | 9-speed shiftable automatic |
| Drivetrain | AWD | AWD |
| Fuel Economy | ||
| City MPG | 24 | 22 |
| Highway MPG | 33 | 31 |
| Combined MPG | 27 | 25 |
| Fuel Tank | 17.4 gal | 17.4 gal |
| Annual Fuel Cost (EPA) | $2,150/yr | No published data |
| Dimensions | ||
| Curb Weight | 4,189 lbs | 4,376 lbs |
| Wheelbase | 116.6" | 116.6" |
| Length | 194.9" | 194.9" |
| Width | 74.0" | 74.0" |
| Height | 57.9" | 57.9" |
| Warranty | ||
| Bumper-to-Bumper | 4yr/50k | 4yr/50k |
| Powertrain | 4yr/50k | 4yr/50k |
| Corrosion | 4yr/50k | 4yr/50k |
| Roadside Assistance | 4yr/50k | 4yr/50k |
Data sources: licensed third-party automotive data, EPA fueleconomy.gov, NHTSA, and official manufacturer materials. Values marked est. are estimated.
2025 Mercedes-Benz E-Class E 350 4MATIC vs E 450 4MATIC Questions Shoppers Ask
Use this page for the direct trim answer, then zoom back out to the Mercedes-Benz E-Class lineup, the Mercedes-Benz brand hub, the Midsize Sedans, the how to pick a trim guide, or our mid-trim value research when you need the bigger shopping path behind this one matchup.
How much more does the 2025 E-Class E 450 4MATIC cost than the E 350 4MATIC?
The E 450 4MATIC starts at $70,850 compared to $64,950 for the E 350 4MATIC. That is a $5,900 difference, or approximately $104/month more on a 60-month loan.
Do the 2025 Mercedes-Benz E-Class E 350 4MATIC and E 450 4MATIC have the same engine?
No. The E 350 4MATIC uses a 2.0L I4 mild-hybrid Turbo (255 hp, 295 lb-ft), while the E 450 4MATIC has the 3.0L I6 mild-hybrid Turbo (375 hp, 369 lb-ft). That is 120 more horsepower. Both pair with the same 9-speed shiftable automatic.
Do the 2025 E-Class E 350 4MATIC and E 450 4MATIC have the same drivetrain?
Yes. Both come with AWD as standard. The differences between these trims are in features and equipment, not drivetrain.
What warranty does the 2025 Mercedes-Benz E-Class come with?
All 2025 Mercedes-Benz E-Class trims, including both the E 350 4MATIC and E 450 4MATIC, come with Mercedes-Benz's standard warranty: 4yr/50k bumper-to-bumper and 4yr/50k powertrain coverage. Warranty does not vary by trim level.
Is the 2025 Mercedes-Benz E-Class E 450 4MATIC worth $5,900 more than the E 350 4MATIC?
The $5,900 buys the 3.0L I6 mild-hybrid Turbo. If that powertrain matters for how you drive, yes. If not, the E 350 4MATIC does the same job for less.
Which 2025 Mercedes-Benz E-Class trim gets better fuel economy, the E 350 4MATIC or the E 450 4MATIC?
The E 350 4MATIC is the more efficient of the two at 27 combined MPG, versus 25 for the other trim. That matters most if you are balancing running costs against the extra power, drivetrain, or comfort equipment tied to the pricier trim.
The Full Story Behind This Price Gap
Use the direct answer above for this exact matchup, then use these guides to understand whether you are really looking at a feature step-up, a package shuffle, or the point where the lineup starts changing in a meaningful way.
Breaking Down the $5,900 Gap
The E 450 4MATIC earns its premium. For $5,900 more, you get the 3.0L I6 mild-hybrid Turbo engine (+120 hp), making this one of the more straightforward upgrade decisions in the E-Class lineup.
How the E 350 4MATIC and E 450 4MATIC Feel Different
Moving from the E 350 4MATIC to the E 450 4MATIC means a different engine entirely. That means 120 more horsepower and 74 more lb-ft of torque. You will notice it most when merging, passing, or climbing at speed. In return, expect about 2 fewer combined MPG.
Fuel Economy Comparison
The E-Class E 350 4MATIC gets 2 more combined MPG. At $3.50/gallon and 12,000 miles/year, that saves roughly $124 per year or $620 over five years of ownership.
The Short Version
The E-Class E 450 4MATIC costs $5,900 more than the E 350 4MATIC (about $104/month more on a 60-month loan). That buys 5 meaningful changes at $1,180 per change. Whether that trade-off is worth it depends on which features matter to your daily driving.
Trim-Matched Accessories
These add-ons are split by trim intent so the recommendations follow the actual use case, not just the same repeated product block.
Mercedes-Benz E-Class E 350 4MATIC
Value-trim add-onsThese picks fit the E 350 4MATIC best when the goal is covering the daily-use gaps without paying up to the next trim.
Mercedes-Benz E-Class E 450 4MATIC
Step-up trim add-onsThese picks suit the E 450 4MATIC when you want the accessories to match the nicer cabin, broader utility, or more premium use case.
As an Amazon Associate, TrimAtlas earns from qualifying purchases.
Specifications shown combine licensed third-party automotive data with official manufacturer, EPA, and NHTSA source material for the 2025 model year. Actual pricing, features, and availability may vary by region and dealer. Always confirm details with an authorized dealer before making a purchase decision. TrimAtlas is not affiliated with Mercedes-Benz or any dealership.
Page updated 2026-03-18. Verify equipment, pricing, and regional availability with the manufacturer or dealer.