2026 Mercedes-Benz E-Class E 350 4MATIC vs 2026 Genesis G80 2.5T
4 mpg better vs $7,950 less and 45 more hp. That is the real fork. Key numbers: 255 vs 300 hp, 27 vs 23 MPG.
The E-Class E 350 4MATIC leads on 4 MPG better. The G80 2.5T leads on $7,950 less, 45 more hp. The spec table compares 7 specifications head to head.
Key Differences at a Glance
What's Actually Different
These two vehicles differ in 7 specifications.
Full Specification Comparison
Specifications and pricing reflect available data as of early 2026 and may not match current manufacturer figures. Always confirm details with an authorized dealer before making a purchase decision.
| Spec | 2026 Mercedes-Benz E-Class E 350 4MATIC | 2026 Genesis G80 2.5T |
|---|---|---|
| Pricing | ||
| MSRP | $66,400 | $58,450 |
| Powertrain | ||
| Engine | 2.0L I4 mild-hybrid Turbo | 2.5L I4 Turbo |
| Horsepower | 255 hp | 300 hp |
| Torque | 295 lb-ft | 311 lb-ft |
| Transmission | 9-speed shiftable automatic | 8-speed shiftable automatic |
| Drivetrain | AWD | AWD |
| Fuel Economy | ||
| City MPG | 24 | 20 |
| Highway MPG | 33 | 29 |
| Combined MPG | 27 | 23 |
| Fuel Tank | 17.4 gal | 17.2 gal |
| Annual Fuel Cost (EPA) | $2,150/yr | $2,500/yr |
| Dimensions | ||
| Curb Weight | 4,189 lbs | 4,431 lbs |
| Wheelbase | 116.6" | 118.5" |
| Length | 194.9" | 197.0" |
| Width | 74.0" | 75.8" |
| Height | 57.9" | 57.7" |
| Safety | ||
| NHTSA Overall | No published data | 5/5 stars |
| IIHS Award | No published data | TSP+ |
| Warranty | ||
| Bumper-to-Bumper | 4yr/50k | 5yr/60k |
| Powertrain | 4yr/50k | 10yr/100k |
| Corrosion | 4yr/50k | 5yr/unlimited |
| Roadside Assistance | 4yr/50k | 5yr/unlimited |
Frequently Asked Questions
What is the price difference between the 2026 Mercedes-Benz E-Class E 350 4MATIC and 2026 Genesis G80 2.5T?
The 2026 Genesis G80 2.5T starts at $58,450, $7,950 less than the 2026 Mercedes-Benz E-Class E 350 4MATIC at $66,400. On a 60-month loan that is roughly $140/month. All prices are MSRP before destination and dealer fees.
Who should choose the 2026 Mercedes-Benz E-Class E 350 4MATIC?
The 2026 Mercedes-Benz E-Class E 350 4MATIC is the stronger pick when lower running costs matter to you, roughly $270/year less on fuel.
Who should choose the 2026 Genesis G80 2.5T?
The 2026 Genesis G80 2.5T is the stronger pick when you want to keep $7,950 in your pocket and the 2026 Genesis G80 2.5T covers your needs; the extra 45 hp matters for your commute or driving style.
Which gets better fuel economy, the 2026 Mercedes-Benz E-Class E 350 4MATIC or 2026 Genesis G80 2.5T?
The 2026 Mercedes-Benz E-Class E 350 4MATIC rates 27 combined MPG, 4 MPG ahead.
Which is more powerful, the 2026 Mercedes-Benz E-Class E 350 4MATIC or 2026 Genesis G80 2.5T?
The 2026 Genesis G80 2.5T produces 300 hp, 45 more than the 2026 Mercedes-Benz E-Class E 350 4MATIC at 255 hp. The 2026 Genesis G80 2.5T also leads in torque at 311 lb-ft vs 295 lb-ft. The 2026 Mercedes-Benz E-Class E 350 4MATIC runs a 2.0L I4 mild-hybrid Turbo; the 2026 Genesis G80 2.5T uses a 2.5L I4 Turbo.
Is the 2026 Mercedes-Benz E-Class E 350 4MATIC bigger than the 2026 Genesis G80 2.5T?
The 2026 Genesis G80 2.5T is 2.1″ longer at 197.0″ vs 194.9″. The 2026 Genesis G80 2.5T has a 1.9″ longer wheelbase, which typically means more rear-seat legroom.
How do the warranties compare?
The Mercedes-Benz E-Class comes with 4yr/50k bumper-to-bumper and 4yr/50k powertrain. The Genesis G80 offers 5yr/60k bumper-to-bumper and 10yr/100k powertrain. Longer warranty coverage can offset higher maintenance costs over time.
Explore more: Mercedes-Benz trims, Mercedes-Benz E-Class trims, Genesis trims, Genesis G80 trims
- 2026 Genesis G80 2.5T Safety Ratings (NHTSA)
- Compare Fuel Economy (EPA)
E-Class vs G80: What This Matchup Is Really About
The 2026 Mercedes-Benz E-Class E 350 4MATIC and 2026 Genesis G80 2.5T are both midsize sedans competing for the same buyer. Price, fuel economy, and daily comfort are the tie-breakers. The $-7,950 gap adds up to $140/month on a 60-month loan. That is real money, so the pricier option needs to earn it with capabilities you will actually use.
Under the Hood
The 2026 Mercedes-Benz E-Class E 350 4MATIC runs a 2.0L I4 mild-hybrid Turbo; the 2026 Genesis G80 2.5T uses a 2.5L I4 Turbo. The 2026 Genesis G80 2.5T has 45 more hp (300 vs 255), enough to notice on highway on-ramps and when passing. Both use AWD.
Running Costs: E-Class vs G80
The 2026 Mercedes-Benz E-Class E 350 4MATIC saves roughly $270/year on fuel at $3.50/gallon and 12,000 annual miles. Over five years, that is $1,350.
Bottom Line
Choose the 2026 Mercedes-Benz E-Class E 350 4MATIC when lower running costs matter to you, roughly $270/year less on fuel. Choose the 2026 Genesis G80 2.5T when you want to keep $7,950 in your pocket and the 2026 Genesis G80 2.5T covers your needs.
Specifications shown combine licensed third-party automotive data with official manufacturer, EPA, and NHTSA source material. Actual pricing, features, and availability may vary by region and dealer. Always confirm details with an authorized dealer before making a purchase decision. TrimAtlas is not affiliated with Mercedes-Benz or Genesis or any dealership.