2026 Mercedes-Benz E-Class E 350 4MATIC vs 2026 Audi A6 Premium
On paper, the 2026 Audi A6 Premium wins on $2,300 less, 107 more hp, 111 more lb-ft torque. The 2026 Mercedes-Benz E-Class E 350 4MATIC has to win you at the dealer. Key numbers: 255 vs 362 hp, 27 vs 23 MPG.
The E-Class E 350 4MATIC leads on 4 MPG better. The A6 Premium leads on $2,300 less, 107 more hp. The spec table compares 6 specifications head to head.
Key Differences at a Glance
What's Actually Different
These two vehicles differ in 6 specifications.
Full Specification Comparison
Specifications and pricing reflect available data as of early 2026 and may not match current manufacturer figures. Always confirm details with an authorized dealer before making a purchase decision.
| Spec | 2026 Mercedes-Benz E-Class E 350 4MATIC | 2026 Audi A6 Premium |
|---|---|---|
| Pricing | ||
| MSRP | $66,400 | $64,100 |
| Powertrain | ||
| Engine | 2.0L I4 mild-hybrid Turbo | 3.0L V6 mild-hybrid Turbo |
| Horsepower | 255 hp | 362 hp |
| Torque | 295 lb-ft | 406 lb-ft |
| Transmission | 9-speed shiftable automatic | 7-speed automated manual |
| Drivetrain | AWD | AWD |
| Fuel Economy | ||
| City MPG | 24 | 20 |
| Highway MPG | 33 | 29 |
| Combined MPG | 27 | 23 |
| Fuel Tank | 17.4 gal | 19.3 gal |
| Annual Fuel Cost (EPA) | $2,150/yr | No published data |
| Dimensions | ||
| Curb Weight | 4,189 lbs | 4,310 lbs |
| Wheelbase | 116.6" | 115.1" |
| Length | 194.9" | 196.8" |
| Width | 74.0" | 73.8" |
| Height | 57.9" | 57.4" |
| Safety | ||
| NHTSA Overall | No published data | 5/5 stars |
| Warranty | ||
| Bumper-to-Bumper | 4yr/50k | 4yr/50k |
| Powertrain | 4yr/50k | 4yr/50k |
| Corrosion | 4yr/50k | 12yr/unlimited |
| Roadside Assistance | 4yr/50k | 4yr/unlimited |
Frequently Asked Questions
What is the price difference between the 2026 Mercedes-Benz E-Class E 350 4MATIC and 2026 Audi A6 Premium?
The 2026 Audi A6 Premium starts at $64,100, $2,300 less than the 2026 Mercedes-Benz E-Class E 350 4MATIC at $66,400. On a 60-month loan that is roughly $40/month. All prices are MSRP before destination and dealer fees.
Who should choose the 2026 Mercedes-Benz E-Class E 350 4MATIC?
The 2026 Mercedes-Benz E-Class E 350 4MATIC is the stronger pick when lower running costs matter to you, roughly $270/year less on fuel.
Who should choose the 2026 Audi A6 Premium?
The 2026 Audi A6 Premium is the stronger pick when you want to keep $2,300 in your pocket and the 2026 Audi A6 Premium covers your needs; the extra 107 hp matters for your commute or driving style.
Which gets better fuel economy, the 2026 Mercedes-Benz E-Class E 350 4MATIC or 2026 Audi A6 Premium?
The 2026 Mercedes-Benz E-Class E 350 4MATIC rates 27 combined MPG, 4 MPG ahead.
Which is more powerful, the 2026 Mercedes-Benz E-Class E 350 4MATIC or 2026 Audi A6 Premium?
The 2026 Audi A6 Premium produces 362 hp, 107 more than the 2026 Mercedes-Benz E-Class E 350 4MATIC at 255 hp. The 2026 Audi A6 Premium also leads in torque at 406 lb-ft vs 295 lb-ft. The 2026 Mercedes-Benz E-Class E 350 4MATIC runs a 2.0L I4 mild-hybrid Turbo; the 2026 Audi A6 Premium uses a 3.0L V6 mild-hybrid Turbo.
Is the 2026 Mercedes-Benz E-Class E 350 4MATIC bigger than the 2026 Audi A6 Premium?
The 2026 Audi A6 Premium is 1.9″ longer at 196.8″ vs 194.9″. The 2026 Mercedes-Benz E-Class E 350 4MATIC has a 1.5″ longer wheelbase, which typically means more rear-seat legroom.
How do the warranties compare?
Both offer similar warranty coverage: 4yr/50k bumper-to-bumper and 4yr/50k powertrain.
Explore more: Mercedes-Benz trims, Mercedes-Benz E-Class trims, Audi trims, Audi A6 trims
- 2026 Audi A6 Premium Safety Ratings (NHTSA)
- Compare Fuel Economy (EPA)
How the E-Class and A6 Stack Up
Two midsize sedans, two brands, and a decision that comes down to which one fits your commute and budget. The 2026 Mercedes-Benz E-Class E 350 4MATIC starts at $66,400; the 2026 Audi A6 Premium at $64,100. The $-2,300 gap is about $40/month on a 60-month loan. Noticeable but not dramatic enough to be the deciding factor on its own.
Powertrain: E-Class vs A6
The 2026 Mercedes-Benz E-Class E 350 4MATIC runs a 2.0L I4 mild-hybrid Turbo; the 2026 Audi A6 Premium uses a 3.0L V6 mild-hybrid Turbo. The 2026 Audi A6 Premium has 107 more hp (362 vs 255). You will feel the difference merging, passing, and driving with a full car. The 2026 Audi A6 Premium adds 111 more lb-ft of torque (406 vs 295), giving it stronger low-end pull off the line. Both use AWD.
What It Actually Costs to Own
The 2026 Mercedes-Benz E-Class E 350 4MATIC saves roughly $270/year on fuel at $3.50/gallon and 12,000 annual miles. Over five years, that is $1,350.
Which One Should You Buy?
Choose the 2026 Mercedes-Benz E-Class E 350 4MATIC when lower running costs matter to you, roughly $270/year less on fuel. Choose the 2026 Audi A6 Premium when you want to keep $2,300 in your pocket and the 2026 Audi A6 Premium covers your needs.
Specifications shown combine licensed third-party automotive data with official manufacturer, EPA, and NHTSA source material. Actual pricing, features, and availability may vary by region and dealer. Always confirm details with an authorized dealer before making a purchase decision. TrimAtlas is not affiliated with Mercedes-Benz or Audi or any dealership.