2025 Lexus RX 350h vs 2025 Mazda CX-50 2.5 S Premium
On paper, the 2025 Lexus RX 350h wins on 8 MPG better, 59 more hp, 48 more lb-ft torque. The 2025 Mazda CX-50 2.5 S Premium has to win you at the dealer. Key numbers: 246 vs 187 hp, 36 vs 28 MPG.
The RX 350h leads on 8 MPG better, 59 more hp. The CX-50 2.5 S Premium leads on $17,225 less. The spec table compares 6 specifications head to head.
Key Differences at a Glance
What's Actually Different
These two vehicles differ in 6 specifications.
Full Specification Comparison
Specifications and pricing reflect available data as of early 2026 and may not match current manufacturer figures. Always confirm details with an authorized dealer before making a purchase decision.
| Spec | 2025 Lexus RX 350h | 2025 Mazda CX-50 2.5 S Premium |
|---|---|---|
| Pricing | ||
| MSRP | $51,425 | $34,200 |
| Powertrain | ||
| Engine | 2.5L I4 hybrid | 2.5L I4 |
| Horsepower | 246 hp | 187 hp |
| Torque | 233 lb-ft | 185 lb-ft |
| Transmission | continuously variable-speed automatic | 6-speed shiftable automatic |
| Drivetrain | AWD | AWD |
| Fuel Economy | ||
| City MPG | 37 | 25 |
| Highway MPG | 34 | 31 |
| Combined MPG | 36 | 28 |
| Fuel Tank | 17.2 gal | 15.9 gal |
| Dimensions | ||
| Curb Weight | 4,480 lbs | 3,741 lbs |
| Wheelbase | 112.2" | 110.8" |
| Length | 192.5" | 185.8" |
| Width | 75.6" | 75.6" |
| Height | 67.3" | 63.5" |
| Safety | ||
| NHTSA Overall | 5/5 stars | 5/5 stars |
| IIHS Award | No published data | TSP+ |
| Warranty | ||
| Bumper-to-Bumper | 4yr/50k | 3yr/36k |
| Powertrain | 6yr/70k | 5yr/60k |
| Corrosion | 6yr/unlimited | 5yr/unlimited |
| Roadside Assistance | 4yr/unlimited | 3yr/36k |
Frequently Asked Questions
What is the price difference between the 2025 Lexus RX 350h and 2025 Mazda CX-50 2.5 S Premium?
The 2025 Mazda CX-50 2.5 S Premium starts at $34,200, $17,225 less than the 2025 Lexus RX 350h at $51,425. On a 60-month loan that is roughly $304/month. All prices are MSRP before destination and dealer fees.
Who should choose the 2025 Lexus RX 350h?
The 2025 Lexus RX 350h is the stronger pick when lower running costs matter to you, roughly $333/year less on fuel; the extra 59 hp matters for your commute or driving style.
Who should choose the 2025 Mazda CX-50 2.5 S Premium?
The 2025 Mazda CX-50 2.5 S Premium is the stronger pick when you want to keep $17,225 in your pocket and the 2025 Mazda CX-50 2.5 S Premium covers your needs.
Which gets better fuel economy, the 2025 Lexus RX 350h or 2025 Mazda CX-50 2.5 S Premium?
The 2025 Lexus RX 350h rates 36 combined MPG, 8 MPG ahead.
Which is more powerful, the 2025 Lexus RX 350h or 2025 Mazda CX-50 2.5 S Premium?
The 2025 Lexus RX 350h produces 246 hp, 59 more than the 2025 Mazda CX-50 2.5 S Premium at 187 hp. The 2025 Lexus RX 350h also leads in torque at 233 lb-ft vs 185 lb-ft. The 2025 Lexus RX 350h runs a 2.5L I4 hybrid; the 2025 Mazda CX-50 2.5 S Premium uses a 2.5L I4.
Is the 2025 Lexus RX 350h bigger than the 2025 Mazda CX-50 2.5 S Premium?
The 2025 Lexus RX 350h is 6.7″ longer at 192.5″ vs 185.8″. The 2025 Lexus RX 350h has a 1.4″ longer wheelbase, which typically means more rear-seat legroom.
How do the warranties compare?
The Lexus RX comes with 4yr/50k bumper-to-bumper and 6yr/70k powertrain. The Mazda CX-50 offers 3yr/36k bumper-to-bumper and 5yr/60k powertrain. Longer warranty coverage can offset higher maintenance costs over time.
Explore more: Lexus trims, Lexus RX trims, Mazda trims, Mazda CX-50 trims
How the RX and CX-50 Stack Up
Two midsize SUVs, two different takes on daily versatility. The 2025 Lexus RX 350h ($51,425) and 2025 Mazda CX-50 2.5 S Premium ($34,200) solve similar problems in different ways. The $-17,225 gap adds up to $304/month on a 60-month loan. That is real money, so the pricier option needs to earn it with capabilities you will actually use.
Powertrain: RX vs CX-50
The 2025 Lexus RX 350h runs a 2.5L I4 hybrid; the 2025 Mazda CX-50 2.5 S Premium uses a 2.5L I4. The 2025 Lexus RX 350h has 59 more hp (246 vs 187). You will feel the difference merging, passing, and driving with a full car. The 2025 Lexus RX 350h adds 48 more lb-ft of torque (233 vs 185), giving it stronger low-end pull off the line. Both use AWD.
What It Actually Costs to Own
The 2025 Lexus RX 350h saves roughly $333/year on fuel at $3.50/gallon and 12,000 annual miles. Over five years, that is $1,665.
Size, Space, and Daily Reality
The 2025 Lexus RX 350h weighs 739 lbs more. Heavier vehicles tend to feel more planted at highway speed but use more fuel and are harder to stop quickly.
Which One Should You Buy?
Choose the 2025 Lexus RX 350h when lower running costs matter to you, roughly $333/year less on fuel. Choose the 2025 Mazda CX-50 2.5 S Premium when you want to keep $17,225 in your pocket and the 2025 Mazda CX-50 2.5 S Premium covers your needs.
Specifications shown combine licensed third-party automotive data with official manufacturer, EPA, and NHTSA source material. Actual pricing, features, and availability may vary by region and dealer. Always confirm details with an authorized dealer before making a purchase decision. TrimAtlas is not affiliated with Lexus or Mazda or any dealership.